A Response to Andrea R. Halpern's Commentary

Should Priority Setting Also Be Concerned About Profound Socio-Economic Transformations? A Response to Recent Commentary

Common DRG System - the Future of Europe? A Response to Recent Commentary

Andrea Cooper: Using pathogens to probe the immune response

When dendritic cells (DCs) patrolling the perimeter of the lung encounter the bacterial intruder Mycobacterium tuberculosis , they trigger a series of location-specific events that culminate in an immune attack on the bug. DCs first secrete the cytokine interleukin (IL)-12p40, which helps the cells migrate from the lung to the draining lymph node, where they present M. tuberculosis antigens to ...

Response to Stampfer Commentary

Steve Hickey, Hilary Roberts The Cochrane review by Douglas et al. [1], which is referenced in the Best Practice article by Douglas and Hemilä [2], covers 60 years of research into vitamin C and the common cold. However, the review omits pharmacokinetic data that invalidate the conclusion that vitamin C is ineffective. This conclusion is not derivable from the data presented. The dual-phase pha...

Authors Response to Commentary

AUTHORS’ RESPONSE Although the initial diagnosis of appendicitis remains a clinical one, laparoscopy has gone some way in aiding management of acute right iliac fossa pain. However, even this remains fallible with a number of normal looking appendices being proven histologically to be inflammed. The significance of this level of inflammation remains controversial, and indeed our study showed no...